VSV-hIFNbeta-NIS

VSV-hIFNbeta-NIS in Treating Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia, Lymphomas, or Histiocytic/Dendritic Cell Neoplasms

What's the purpose of the trial?

This phase I trial studies the best dose and side effects of the VSV-hIFNβ-NIS vaccine with or without cyclophosphamide and combinations of ipilimumab, nivolumab, and cemiplimab in treating patients with multiple myeloma, acute myeloid leukemia or lymphoma that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory).

Trial status

Accepting patients

Phase
Phase 1
Enrollment
65
Last Updated
4 months ago
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Participating Centers

There are 3 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Cemiplimab (REGN2810) is a monoclonal antibody that attaches to the PD-1 protein on the body's immune cells. Cemiplimab may work by stopping cancer cells from being able to inhibit the body's immune system.
  • Ipilimumab is a monoclonal antibody that is approved to treat melanoma, and several other cancers in combination with other therapies.
  • Ruxolitinib is a tyrosine kinase inhibitor in development for the treatment of several different blood cancers.
  • VSV-hIFNbeta-NIS IV is a virus that has been altered in a laboratory and is being evaluated to see if it may be able to kill cancer cells without damaging normal cells.

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