OPN-662

A Phase 1b, Dose Escalation/Dose Expansion, Multicenter, Open-Label Study to Assess the Safety and Tolerability of OPN-6602 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and/or Refractory Multiple Myeloma

What's the purpose of the trial?

Phase 1b, open-label study evaluating the safety, tolerability, pharmacokinetics, preliminary antitumor activity, and pharmacodynamics of OPN-6602 monotherapy and in combination with dexamethasone in subjects with relapsed and/or refractory MM.

Trial status

Accepting patients

Phase

Phase 1

Enrollment

130

Last Updated

1 month ago

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Participating Centers

There are 5 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

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Dexamethasone is a corticosteroid that prevents the release of substances in the body that cause inflammation, and is given in conjunction with some cancer treatments.
OPN-6602 is a type of drug called a bromodomain inhibitor that targets the p300 and CREB-binding protein found on some cancer cells. This drug may work by blocking cancer cells from growing and multiplying.

Arms / Cohorts

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Accepting patients

Dose Escalation

Accepting patients

Dose Escalation: OPN-6602 + Dexamethasone

Not yet accepting

Dose Expansion

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