BMF-219

A Phase 1 First-in-human Dose-escalation and Dose-expansion Study of BMF-219, an Oral Covalent Menin Inhibitor, in Adult Patients With Acute Leukemia (AL), Diffuse Large B-cell Lymphoma (DLBCL), Multiple Myeloma (MM), and Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL)

What's the purpose of the trial?

A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-219, an oral covalent menin inhibitor, in adult patients with AML, ALL (with KMT2A/ MLL1r, NPM1 mutations), DLBCL, MM, and CLL/SLL.

Trial status

Accepting patients

Phase

Phase 1

Enrollment

177

Last Updated

1 week ago

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Participating Centers

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Experimental Treatments

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BMF-219 is a kind of drug called a covalent menin inhibitor. BMF-219 may work by blocking proteins that cancer cells need to survive and grow.

Arms / Cohorts

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Accepting patients

Dose Expansion: BMF-219

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