Iber-KDd

Phase 2, Single-Arm Study of Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma

What's the purpose of the trial?

The investigators want to find out whether or not giving patients who have relapsed or refractory multiple myeloma (MM) the experimental medication combination iberdomide, carfilzomib, daratumumab, and dexamethasone (Iber-KDd) may produce better results than the current (standard of care) treatments.

Trial status

Accepting patients

Phase
Phase 2
Enrollment
30
Last Updated
3 months ago
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Participating Centers

There is one center participating in this trial. Enter a location below to view the distance.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Acetaminophen is an analgesic medication that is commonly used to treat minor pain and to reduce fevers.
  • Carfilzomib Carfilzomib is a kind of medication called a proteasome inhibitor that interferes with the growth and spread of cancer cells in the body. Carfilzomib is used in the treatment of multiple myeloma. 
  • Daratumumab is a type of cancer drug called a monoclonal antibody. Daratumumab attaches to a protein called CD38, which is present in high numbers on the surface of multiple myeloma cells, as well as on certain other types of cells, such as red blood cells.
  • Dexamethasone is a corticosteroid that prevents the release of substances in the body that cause inflammation, and is given in conjunction with some cancer treatments.
  • Diphenhydramine is an antihistamine medication that is used to treat several different indications. Antihistamines are often used to treat allergies or to prevent allergic reactions to medications.
  • Iberdomide is a Cereblon (CRBN) binding compound currently under clinical investigation for multiple myeloma.
  • Montelukast Montelukast is a kind of drug called a leukotriene receptor antagonist. Montelukast is commonly used to treat asthma and symptoms associated with allergies.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

Iberdomide + Carfilzomib + Daratumumab + Dexamethasone

Accepting patients

Iberdomide

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