MonumenTAL-3

Phase 3 Clinical Trial Comparing the Efficacy of an Investigational Medication Combined with Daratumumab or Daratumumab and Pomalidomide Versus Daratumumab, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma.

What will happen during the trial?

This trial is organized into 28-day cycles. Participants in this trial will be randomly assigned in to one of three different groups, or arms. Participants in all arms may receive pre-treatment medications to help minimize the risk of side effects from the study drugs.

Treatment Involved

The investigational medication being studied is a type of drug called a bispecific antibody. Bispecific antibodies are drugs that have two different targets. This investigational medication’s two targets are CD3, a receptor found on our own T cells, and GPRC5D, a protein found on the surface of some myeloma cells. The investigational medication is being evaluated to determine if once in the body, it will draw the body’s T cells and myeloma cells closer together, resulting in T cell activation and myeloma cell death. 

More Information

Trial Status
Accepting patients
Trial Phase
Phase 3
Enrollment
810 patients (estimated)
Sponsors
Janssen Research & Development LLC
Tags
Bispecific Antibody, CD3, GPRC5D, Randomization
Trial Type
Treatment
Last Update
1 month ago
SparkCures ID
1328
NCT Identifier
NCT05455320

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