P-BCMA-ALLO1

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma (MM)

What will happen during the trial?

Phase 1/1b study: Phase 1 Part 1 is a weight-based dose escalation following a 3+3 design of dose-escalating cohorts. Phase 1 Part 2 includes administration at fixed doses. After enrollment, subjects may receive a lymphodepletion therapy regimen before administration of allogeneic CAR-T cells, administered as a single or multiple doses. Treated subjects will undergo serial measurements of safety, tolerability and response. Rimiducid may be administered as indicated. Phase 1b of the study will undergo further expansion of cohorts/arms from Phase 1 Parts 1 or 2 to guide selection of Recommended Phase 2 Dose (RP2D).

More Information

Trial Status
Accepting patients
Trial Phase
Phase 1
Enrollment
231 patients (estimated)
Sponsors
Poseida Therapeutics, Inc.
Collaborators
Genentech
Tags
CAR T Cell (Allogeneic), B-Cell Maturation Antigen (BCMA)
Trial Type
Treatment
Last Update
2 weeks ago
SparkCures ID
1251
NCT Identifier
NCT04960579

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