Smilow Cancer Hospital at Yale New Haven

New Haven, CT

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Accepting patients

Talisman

A Phase 2, Open-label, Randomized Study to Evaluate Prophylactic Interventions on Talquetamab-related Oral Toxicity
  • Bispecific Antibody
  • GPRC5D
  • Randomization
  • Phase 2

Accepting patients

BMS-986453

A Phase 1, Open-Label, Dose-Finding Study of BMS-986453, Dual Targeting BCMAxGPRC5D Chimeric Antigen Receptor T Cells, in Participants With Relapsed and/or Refractory Multiple Myeloma
  • CAR T Cell
  • BCMA
  • GPRC5D
  • Phase 1

Accepting patients

MajesTEC-7

A Study to Compare Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7)
  • Bispecific Antibody
  • BCMA
  • Randomization
  • Phase 3
  • Has results

Not yet accepting

DURGA-4

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
  • CAR T Cell
  • CD19
  • BCMA
  • Randomization
  • Phase 3

Accepting patients

TRIlogy-4

A Phase 3 Randomized Study Comparing JNJ-79635322 and an Anti-BCMAxCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti CD38 Antibody
  • T Cell Engager (TCE)
  • Trispecific Antibody
  • BCMA
  • CD3
  • GPRC5D
  • Randomization
  • Phase 3

Accepting patients

SubQSA

A Single-arm, Open-label, Phase 2 Study Evaluating Subcutaneous Administration of Isatuximab, Administered by an On Body Delivery System, in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (RRMM)
  • Monoclonal Antibody
  • CD38
  • Phase 2

Accepting patients

ROTATE

Engaging T-cells to Eliminate MRD in Newly Diagnosed Myeloma Optimizing Response With Talquetmab and Teclistamab (ROTATE) (ROTATE)
  • Bispecific Antibody
  • GPRC5D
  • BCMA
  • Minimal Residual Disease (MRD)
  • Post-Autologous Stem Cell Transplant
  • Phase 2

Accepting patients

TECVAYLI

A Phase 1b Trial of Teclistamab in Combination With Iberdomide for Relapsed/Refractory Multiple Myeloma
  • CELMoD
  • Bispecific Antibody
  • BCMA
  • Phase 1

Accepting patients

Surzetoclax (ABBV-453)

A Phase 1/2, Open-Label, Platform Study to Evaluate Safety and Efficacy of the BCL-2 Inhibitor Surzetoclax (ABBV-453) Given as Monotherapy or in Combination With Antimyeloma Regimens in Subjects With Multiple Myeloma
  • BCL-2 Inhibitor
  • Phase 1/2

Accepting patients

Elranatamab and Mezigdomide Combination Therapy

A Phase 1b/2a, Multicenter, Open-label Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
  • Bispecific Antibody
  • BCMA
  • CD3
  • Randomization
  • Phase 1/2
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