University of Alabama at Birmingham

O'Neal Comprehensive Cancer Center

Birmingham, AL

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QUINTESSENTIAL

Phase 2 Study of BMS-986393, a GPRC5D-directed CART-Cell Therapy, in Participants with Relapsed or Refractory Multiple Myeloma
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  • CAR T Cell
  • GPRC5D
  • Phase 2

Accepting patients

BMS-986453

A Phase 1, Open-Label, Dose-Finding Study of BMS-986453, Dual Targeting BCMAxGPRC5D Chimeric Antigen Receptor T Cells, in Participants With Relapsed and/or Refractory Multiple Myeloma
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  • CAR T Cell
  • BCMA
  • GPRC5D
  • Phase 1

Accepting patients

CA088-1005

A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma and Determine the Recommended Dose for Each Add-on Investigational Component
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  • CAR T Cell
  • CELMoD
  • GPRC5D
  • Phase 1

Accepting patients

GCO12F CAR-T

A Phase 1b/2 Study of GC012F, a Chimeric Antigen Receptor T-cell (CAR T) Therapy Targeting CD19 and B-cell Maturation Antigen (BCMA) in Subjects With Relapsed/Refractory Multiple Myeloma
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  • CAR T Cell
  • BCMA
  • CD19
  • Phase 1/2

Accepting patients

MonumenTAL-1

Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma (MonumenTAL-1)
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  • Bispecific Antibody
  • GPRC5D
  • Phase 1
  • Has results

Accepting patients

BGB-11417

A Phase 1b/2 Study of BGB-11417 in Monotherapy and in Various Combinations With Dexamethasone and Carfilzomib in Multiple Myeloma
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  • BCL-2 Inhibitor
  • Phase 1/2
  • Has results

Accepting patients

IMPEDE

Isatuximab, Pomalidomide, Elotuzumab and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma
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  • Monoclonal Antibody
  • CD38
  • Phase 2
  • Has results

Accepting patients

MILESTONE

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)
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  • Monoclonal Antibody
  • CD38
  • Phase 2

Accepting patients

COMMANDER

COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide (COMMANDER)
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  • CELMoD
  • Monoclonal Antibody
  • CD38
  • Phase 1/2

Accepting patients

CaMMouflage

A Phase 1, Multicenter, Open-Label Study of CB-011, a CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma (CaMMouflage Trial)
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  • CAR T Cell (Allogeneic)
  • BCMA
  • Phase 1
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